Control of somatic tissue differentiation by the long non-coding RNA TINCR.
Nature. 2012 Dec 2
Kretz M, Siprashvili Z, Chu C, Webster DE, ..., Raj A, Rinn JL, Chang HY, Khavari PA. Kretz M, Siprashvili Z, Chu C, Webster DE, Zehnder A, Qu K, Lee CS, Flockhart RJ, Groff AF, Chow J, Johnston D, Kim GE, Spitale RC, Flynn RA, Zheng GXY, Aiyer S, Raj A, Rinn JL, Chang HY, Khavari PA. Nature. 2012 Dec 2
This is an interesting paper that outlines a new role for a long non-coding RNA (lncRNA) in controlling human epidermal differentiation by a post-transcriptional mechanism. This 3.7-kilobase (kb) cytoplasmic lncRNA, named terminal differentiation-induced ncRNA (TINCR), is mostly expressed during differentiation, and is in fact downregulated...
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