SUMOylation Silences Heterodimeric TASK Potassium Channels Containing K2P1 Subunits in Cerebellar Granule Neurons.
Sci Signal. 2012; 5(251):ra84
Joseph Frank Cotten
10 Dec 2012
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New Finding
This study by Plant et al. has several important and novel findings. The authors demonstrate that TWIK-1 (potassium channel subfamily K member 1 [Kcnk1]) tandem pore potassium channels can 1) dimerize with TASK-1 (Kcnk3) or TASK-3 (Kcnk9) subunits, resulting in an acidic pH-inhibited, halothane-activated K+ conductance, 2) confer...
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