DNA breathing dynamics distinguish binding from nonbinding consensus sites for transcription factor YY1 in cells.
Nucleic Acids Res. 2012 Nov 1; 40(20):10116-23
Andrew D Sharrocks
27 Nov 2012
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New Finding
This paper provides evidence for a role of DNA breathing dynamics in enhancing the specificity of transcription factor binding in vivo.
One of the major unanswered questions about transcriptional control mechanisms is how transcription factors distinguish the correct binding sites from multiple different possibilities. The DNA...
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