A surprising observation that oxygen can affect the product enantiopurity of an enzyme-catalysed reaction.
FEBS J. 2012 Nov; 279(22):4160-71
Fryszkowska A, Toogood HS, Mansell D, Stephens G, Gardiner JM, Scrutton NS. FEBS J. 2012 Nov; 279(22):4160-71
The paper describes the puzzling result that oxygen changes the stereochemical outcome of an enzymatic NAD(P)H-dependent reduction that under anoxic conditions yields predominantly the S-isomer with 60% enantiomeric excess (ee), whereas in the presence of air the R-isomer with 50% ee is formed.
One distinct property of enzymes...
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