A surprising observation that oxygen can affect the product enantiopurity of an enzyme-catalysed reaction.
FEBS J. 2012 Nov; 279(22):4160-71
Wolfgang Buckel
19 Nov 2012
|
New Finding
The paper describes the puzzling result that oxygen changes the stereochemical outcome of an enzymatic NAD(P)H-dependent reduction that under anoxic conditions yields predominantly the S-isomer with 60% enantiomeric excess (ee), whereas in the presence of air the R-isomer with 50% ee is formed.
One distinct property of enzymes...
INDIVIDUAL SUBSCRIPTIONS
Get instant access to Article Recommendations from more than 5,000 expert scientists and clinical researchers, assisted by 5,000 associates, by taking out a monthly subscription. The first month of your subscription will be free of charge.
Start your personal subscription today.
Subscribe for $9.95/monthINSTITUTIONAL SUBSCRIPTIONS
Send a recommendation to your institution's librarian or information manager to request an extended free trial for all users.
Recommend to your LibrarianIf you are a librarian or information manager, you may request an extended free trial for your academic or corporate institution.
Request an Institutional Trialyour institution might be eligible for free access via our sponsorship scheme. Check our sponsorship page.
If you think you should be able to access this content, please contact us.