Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance.
Nucleic Acids Res. 2012 Sep 16
Juhasz S, Balogh D, Hajdu I, Burkovics P, Villamil MA, Zhuang Z, Haracska L. Nucleic Acids Res. 2012 Sep 16
This, and five related papers {1-5}, open new avenues into the comprehension of the molecular mechanisms governing DNA polymerase remodelling at forks stalled with DNA lesions.
DNA damage can induce replication stress by halting the progression of replicative DNA polymerases, since they cannot synthesize DNA past a lesion. Cells...
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