Proteome-wide discovery of evolutionary conserved sequences in disordered regions.
Sci Signal. 2012 Mar 13; 5(215):rs1
Nguyen Ba AN, Yeh BJ, van Dyk D, Davidson AR, Andrews BJ, Weiss EL, Moses AM. Sci Signal. 2012 Mar 13; 5(215):rs1
This is the first systematic study dedicated to the focused search for the evolutionary conserved functional elements within disordered regions. An accurate computational tool based on a phylogenetic hidden Markov model (phylo-HMM) was used to systematically detect conserved short linear motifs in unstructured regions in multiple...
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