MicroRNAs are exported from malignant cells in customized particles.
Nucleic Acids Res. 2012 Jul 5
Palma J, Yaddanapudi SC, Pigati L, Havens MA, ..., Weimer KM, Stern B, Hastings ML, Duelli DM. Palma J, Yaddanapudi SC, Pigati L, Havens MA, Jeong S, Weiner GA, Weimer KM, Stern B, Hastings ML, Duelli DM. Nucleic Acids Res. 2012 Jul 5
Since the discovery in 2007 by the group of Lötvall {1} that exosomes, a subclass of secreted membrane vesicles, contain mRNA and micro RNA (miRNA), and can transfer this genetic information to other cells, a strong interest has emerged for this field. This observation suggested that exosomes represented a new, somehow unexpecte means...
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