Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice.
J Exp Med. 2012 Aug 27
Fournier EM, Velez MG, Leahy K, Swanson CL, Rubtsov AV, Torres RM, Pelanda R. J Exp Med. 2012 Aug 27
Via thorough examination in autoimmune disease-prone MRL-lpr mice harboring a human immunoglobulin (Ig) kappa light chain constant region (C-kappa) gene in place of one of the endogenous C-kappa genes as a marker for distinguishing two alleles, the authors demonstrated that dual-kappa B cells expressing Ig kappa chain from both...
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