The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors.
Sci Signal. 2012 Jul 31; 5(235):ra54
Takeshi Tsubata
23 Aug 2012
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New Finding
The authors describe a novel molecular interaction between the cytoplasmic region of membrane-bound IgG and synapse-associated protein 97 (SAP97), a member of the membrane-associated guanylate kinase (MAGUK) family. This interaction appears to be involved in augmented signaling through the IgG-containing B cell antigen receptor...
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