The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors.
Sci Signal. 2012 Jul 31; 5(235):ra54
Liu W, Chen E, Zhao XW, Wan ZP, ..., Aravind L, Swat W, Brzostowski J, Pierce SK. Liu W, Chen E, Zhao XW, Wan ZP, Gao YR, Davey A, Huang E, Zhang L, Crocetti J, Sandoval G, Joyce MG, Miceli C, Lukszo J, Aravind L, Swat W, Brzostowski J, Pierce SK. Sci Signal. 2012 Jul 31; 5(235):ra54
The authors describe a novel molecular interaction between the cytoplasmic region of membrane-bound IgG and synapse-associated protein 97 (SAP97), a member of the membrane-associated guanylate kinase (MAGUK) family. This interaction appears to be involved in augmented signaling through the IgG-containing B cell antigen receptor...
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