Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike.
J Biol Chem. 2012 Jul 23
Christoph Borner
09 Aug 2012
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Controversial, Interesting Hypothesis
This study provides novel insights into the long-standing question of whether caspase-2 is an initiator or an effector caspase. Comparison of the cleavage specificity profile of recombinant human caspase-2 with those of caspase-3 and caspase-7 revealed that 61 out of 68 cleavage sites overlapped (DEVD↓G consensus). This finding...
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