Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel.
Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11866-71
Zhang H, Zou B, Yu H, Moretti A, ..., Tomaselli G, Nan F, Laugwitz KL, Li M. Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, Babcock JJ, Bellin M, McManus OB, Tomaselli G, Nan F, Laugwitz KL, Li M. Proc Natl Acad Sci U S A. 2012 Jul 17; 109(29):11866-71
This interesting study demonstrates that the biophysical characterization of cardiomyocytes generated from fibroblast-derived induced pluripotent stem cells (iPSCs) obtained from patients with long QT syndrome (LQTS) can be used to generate biologically accurate computational models that can be used to reveal the physiological impact...
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