The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.
Cell. 2012 Mar 30; 149(1):146-58
Powell AE, Wang Y, Li Y, Poulin EJ, ..., Aronow BJ, Haigis KM, Franklin JL, Coffey RJ. Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ. Cell. 2012 Mar 30; 149(1):146-58
This paper identifies Lrig1, a transmembrane protein and negative feedback inhibitor of ErbB signaling, as a marker of a rather quiescent population of intestinal and colonic stem cells that have the ability to fully repopulate damaged crypts. The Lrig1+ population is located at the crypt base but appears to differ phenotypically...
Get instant access to Article Recommendations from more than 5,000 expert scientists and clinical researchers, assisted by 5,000 associates, by taking out a monthly subscription. The first month of your subscription will be free of charge.
Start your personal subscription today.Subscribe for $9.95/month
Send a recommendation to your institution's librarian or information manager to request an extended free trial for all users.Recommend to your Librarian
If you are a librarian or information manager, you may request an extended free trial for your academic or corporate institution.Request an Institutional Trial
your institution might be eligible for free access via our sponsorship scheme. Check our sponsorship page.
If you think you should be able to access this content, please contact us.