The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor.
Cell. 2012 Mar 30; 149(1):146-58
Deborah Gumucio and Katherine Walton
30 Jul 2012
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Controversial, New Finding
This paper identifies Lrig1, a transmembrane protein and negative feedback inhibitor of ErbB signaling, as a marker of a rather quiescent population of intestinal and colonic stem cells that have the ability to fully repopulate damaged crypts. The Lrig1+ population is located at the crypt base but appears to differ phenotypically...
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