Long term effects of denufosol tetrasodium in patients with cystic fibrosis.
J Cyst Fibros. 2012 Jun 8
Ratjen F, Durham T, Navratil T, Schaberg A, ..., Wainwright C, Barnes M, Moss RB, the TIGER-2 Study Investigator Group. Ratjen F, Durham T, Navratil T, Schaberg A, Accurso FJ, Wainwright C, Barnes M, Moss RB, the TIGER-2 Study Investigator Group. J Cyst Fibros. 2012 Jun 8
Denufosol stimulates chloride secretion via an alternative channel and phase 2 studies had suggested clinical efficacy in cystic fibrosis (CF). This paper reports the results of the international phase 3 clinical trial of denufosol, which failed to demonstrate efficacy as represented by a change in forced expiratory volume in one...
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