Circadian-related heteromerization of adrenergic and dopamine d(4) receptors modulates melatonin synthesis and release in the pineal gland.
PLoS Biol. 2012 Jun; 10(6):e1001347
González S, Moreno-Delgado D, Moreno E, Pérez-Capote K, ..., Ortiz J, Ferré S, Canela E, McCormick PJ. González S, Moreno-Delgado D, Moreno E, Pérez-Capote K, Franco R, Mallol J, Cortés A, Casadó V, Lluís C, Ortiz J, Ferré S, Canela E, McCormick PJ. PLoS Biol. 2012 Jun; 10(6):e1001347
This article shows for the first time the dynamic regulation of G-protein-coupled receptor (GPCR) heteromer formation in a circadian manner.
The pineal gland is the major site of melatonin synthesis in mammals. Melatonin is synthesized in a two-step synthesis pathway from its precursor, serotonin, in a circadian manner with high...
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