PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.
Sci Signal. 2012 Feb 28; 5(213):ra18
Alex Toker and Kristin Brown
03 Aug 2012
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New Finding
The tumor suppressor phosphatase PTEN (phosphatase and tensin homolog) regulates many cellular processes, most notably cell growth, proliferation and survival. The principal catalytic function of PTEN is as a lipid phosphatase that dephosphorylates phosphatidylinositol-3,4,5-trisphosphate (PIP3) to terminate signaling downstream of...
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