PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity.
Sci Signal. 2012 Feb 28; 5(213):ra18
Tibarewal P, Zilidis G, Spinelli L, Schurch N, ..., Perera NM, Davidson L, Barton GJ, Leslie NR. Tibarewal P, Zilidis G, Spinelli L, Schurch N, Maccario H, Gray A, Perera NM, Davidson L, Barton GJ, Leslie NR. Sci Signal. 2012 Feb 28; 5(213):ra18
The tumor suppressor phosphatase PTEN (phosphatase and tensin homolog) regulates many cellular processes, most notably cell growth, proliferation and survival. The principal catalytic function of PTEN is as a lipid phosphatase that dephosphorylates phosphatidylinositol-3,4,5-trisphosphate (PIP3) to terminate signaling downstream of...
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