Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease.
J Cell Biol. 2012 Mar 5; 196(5):573-87
Philip Coffino
11 Dec 2012
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Interesting Hypothesis
How do proteins with polyglutamine (polyQ) repeats cause neural toxicity? There are multiple dominant hereditary neurological diseases caused by the presence of polyQ tracts. Huntington's disease is one. A longer polyQ tract implies more severe symptoms and/or earlier onset of disease. Inclusion bodies (IBs) are found in the brains...
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