Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.
Cell. 2012 Jul 6; 150(1):122-35
Asencio C, Davidson IF, Santarella-Mellwig R, Ly-Hartig TB, Mall M, Wallenfang MR, Mattaj IW, Gorjánácz M. Cell. 2012 Jul 6; 150(1):122-35
This paper shows how coordinated regulation of protein kinases and phosphatases can be exploited to accomplish complex biological tasks like nuclear envelope formation. In higher eukaryotes, the nuclear membrane breaks down at mitosis and protein phosphorylation plays a crucial role in this control. In particular, phosphorylation...
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