Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma.
Nat Cell Biol. 2012 Aug; 14(8):882-90
Shakhova O, Zingg D, Schaefer SM, Hari L, ..., Dummer R, Barrandon Y, Cinelli P, Sommer L. Shakhova O, Zingg D, Schaefer SM, Hari L, Civenni G, Blunschi J, Claudinot S, Okoniewski M, Beermann F, Mihic-Probst D, Moch H, Wegner M, Dummer R, Barrandon Y, Cinelli P, Sommer L. Nat Cell Biol. 2012 Aug; 14(8):882-90
This paper adds to the growing evidence for the importance of Sox10 upregulation in the progression of melanoma from giant congenital nevi. Sox10 is upregulated in human congenital nevi and in the mouse model of hyperpigmentation and melanoma. Remarkably, Sox10 haploinsufficiency essentially reverts hyperpigmentation and, import melanoma...
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