Cancer Cell. 2012 May 15; 21(5):626-41
This paper reveals an unexpected consequence of the conditional knockout (cKO) of Lunatic Fringe (Lfng) in mouse mammary gland cells that express the mouse mammary tumor virus (MMTV) promoter. At about 10 months of age, cKO Lfng-/- female mice begin to spontaneously develop mammary tumors. In an elegant series of experiments, the...
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