E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch.
Proc Natl Acad Sci U S A. 2012 Jul 16; 109:12568-73
Borghi N, Sorokina M, Shcherbakova OG, Weis WI, Pruitt BL, Nelson WJ, Dunn AR. Proc Natl Acad Sci U S A. 2012 Jul 16; 109:12568-73
This paper demonstrates that E-cadherin is under molecular tension, a prediction of the concept that cadherins serve in mechanotransduction. It also documents the more surprising finding that free cadherin is also under tension, raising the possibility that it may be a general membrane-cytoskeleton anchor.
There is increasing evidence...
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