Efficacy and tolerability of zonisamide versus controlled-release carbamazepine for newly diagnosed partial epilepsy: a phase 3, randomised, double-blind, non-inferiority trial.
Lancet Neurol. 2012 Jul; 11(7):579-88
Baulac M, Brodie MJ, Patten A, Segieth J, Giorgi L. Lancet Neurol. 2012 Jul; 11(7):579-88
This interesting randomized double blind non-inferiority comparative trial demonstrated that zonisamide was non-inferior to controlled release carbamazepine in adults with newly diagnosed partial epilepsy. This trial is one of the few clinical trials conducted according to the 2006 International League against Epilepsy (ILAE) guidelines...
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