TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Nat Immunol. 2012; 13(7):691-700
Chen H, Ndhlovu ZM, Liu D, Porter LC, ..., Douek DC, Kaufmann DE, Allen TM, Walker BD. Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BD. Nat Immunol. 2012; 13(7):691-700
This paper shows that preferential usage of certain advantageous T cell receptors (TCRs) with the ability to contain potential T cell-selected 'escape mutations' is the main factor distinguishing HIV-1-infected donors with viral control from those with the same restricting 'protective' human leukocyte antigen (HLA) alleles who fail...
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