TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Nat Immunol. 2012; 13(7):691-700
Sarah Rowland-Jones and Louis-Marie Yindom
07 Nov 2012
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Interesting Hypothesis, New Finding
This paper shows that preferential usage of certain advantageous T cell receptors (TCRs) with the ability to contain potential T cell-selected 'escape mutations' is the main factor distinguishing HIV-1-infected donors with viral control from those with the same restricting 'protective' human leukocyte antigen (HLA) alleles who fail...
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