Watching DNA polymerase η make a phosphodiester bond.
Nature. 2012 Jul 12; 487(7406):196-201
Nakamura T, Zhao Y, Yamagata Y, Hua YJ, Yang W. Nature. 2012 Jul 12; 487(7406):196-201
By flash freezing crystals of human DNA polymerase eta (Pol eta), DNA template and nucleotides after the addition of Mg2+, the authors could isolate and solve crystal structures of intermediate states of phosphodiester bond formation. The most interesting feature was that transient electron density showed up during the course of the...
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