Refinement of the Magnetic Resonance Diffusion-Perfusion Mismatch Concept for Thrombolytic Patient Selection: Insights From the Desmoteplase in Acute Stroke Trials.
Stroke. 2012 Jul 3
Warach S, Al-Rawi Y, Furlan AJ, Fiebach JB, ..., Smyej J, Bharucha DB, Pedraza S, Rowley HA. Warach S, Al-Rawi Y, Furlan AJ, Fiebach JB, Wintermark M, Lindstén A, Smyej J, Bharucha DB, Pedraza S, Rowley HA. Stroke. 2012 Jul 3
While controversy persists in whether the mismatch hypothesis should be used in clinical practice, this paper defines a minimum threshold of mismatch volume (MMV) that produced a significant benefit in the extended (3- to 9-hour) treatment window, finding that desmoteplase was beneficial in patients with a large perfusion-weighted...
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