Three postpartum antiretroviral regimens to prevent intrapartum HIV infection.
N Engl J Med. 2012 Jun 21; 366(25):2368-79
Nielsen-Saines K, Watts DH, Veloso VG, Bryson YJ, ..., Xu J, Moye J, Mofenson LM, NICHD HPTN 040/PACTG 1043 Protocol Team. Nielsen-Saines K, Watts DH, Veloso VG, Bryson YJ, Joao EC, Pilotto JH, Gray G, Theron G, Santos B, Fonseca R, Kreitchmann R, Pinto J, Mussi-Pinhata MM, Ceriotto M, Machado D, Bethel J, Morgado MG, Dickover R, Camarca M, Mirochnick M, Siberry G, Grinsztejn B, Moreira RI, Bastos FI, Xu J, Moye J, Mofenson LM, NICHD HPTN 040/PACTG 1043 Protocol Team. N Engl J Med. 2012 Jun 21; 366(25):2368-79
Here, a three-arm randomized controlled trial (RCT) of post-natal prophylaxis of HIV-exposed infants (born to mothers who were not on antiretroviral drugs [ARVs] during pregnancy) with one, two or three ARVs demonstrated that the two- (zidovudine+nevaripine) and three-drug (zidovudine+nelfinavir+lamivudine) groups were superior...
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