Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.
J Clin Invest. 2012 Jun 1; 122(6):1991-2005
Felcht M, Luck R, Schering A, Seidel P, ..., Thomas M, Uemura A, Goerdt S, Augustin HG. Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG. J Clin Invest. 2012 Jun 1; 122(6):1991-2005
This is a very interesting manuscript dissecting the role of angiopoietin-2 in angiogenesis. The work by Felcht et al. describes how angiopoietin-2, by activation of integrin signalling in a TIE2-independent manner, stimulates endothelial cell migration and sprouting angiogenesis. This could lead to new therapeutic approaches to controlling...
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