Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.
J Clin Invest. 2012 Jun 1; 122(6):1991-2005
Luigi Gnudi
10 Jul 2012
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New Finding
This is a very interesting manuscript dissecting the role of angiopoietin-2 in angiogenesis. The work by Felcht et al. describes how angiopoietin-2, by activation of integrin signalling in a TIE2-independent manner, stimulates endothelial cell migration and sprouting angiogenesis. This could lead to new therapeutic approaches to controlling...
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