Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
Mol Psychiatry. 2012 Jun 12
Markus Heilig
20 Oct 2012
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Novel Drug Target
This paper is a translational tour de force, pointing to the possibility that potentiation of endocannabinoid transmission may facilitate extinction of fear memories. It uses a novel inhibitor of fatty acid amide hydrolase (FAAH) (AM3506), the enzyme that degrades anandamide, and shows that this drug facilitates fear extinction...
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