Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
Mol Psychiatry. 2012 Jun 12
Gunduz-Cinar O, Macpherson KP, Cinar R, Gamble-George J, ..., Caspi A, Moffitt TE, Kunos G, Holmes A. Gunduz-Cinar O, Macpherson KP, Cinar R, Gamble-George J, Sugden K, Williams B, Godlewski G, Ramikie TS, Gorka AX, Alapafuja SO, Nikas SP, Makriyannis A, Poulton R, Patel S, Hariri AR, Caspi A, Moffitt TE, Kunos G, Holmes A. Mol Psychiatry. 2012 Jun 12
This paper is a translational tour de force, pointing to the possibility that potentiation of endocannabinoid transmission may facilitate extinction of fear memories. It uses a novel inhibitor of fatty acid amide hydrolase (FAAH) (AM3506), the enzyme that degrades anandamide, and shows that this drug facilitates fear extinction...
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