Sci Signal. 2012 May 8; 5(223):ra37
Despite decades of work on protein kinases, the mechanisms by which kinases are maintained in the active state or downregulated by dephosphorylation have been incompletely understood. In this work, the authors addressed a central paradox in this area -- namely why adenosine 5'-triphosphate (ATP) competitive inhibitors of AKT result...
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