Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness.
Aging Cell. 2012 Jun 19
Weiss EP, Villareal DT, Ehsani AA, Fontana L, Holloszy JO.
Aging Cell. 2012 Jun 19
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Hackett G: F1000Prime Recommendation of [Weiss EP et al., Aging Cell 2012]. In F1000Prime, 18 Jul 2012; DOI: 10.3410/f.717948100.793453150. F1000Prime.com/717948100#eval793453150
F1000Prime Recommendations, Dissents and Comments for [Weiss EP et al., Aging Cell 2012]. In F1000Prime, 22 May 2013; F1000Prime.com/717948100
Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, ..., Hayward M, Keogh B, MacAllister RJ, Yellon DM. Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM. Lancet. 2007 Aug 18; 370(9587):575-9
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Anthony Harries 09 Sep 2010
Allison MA, Manson JE, Langer RD, Carr JJ, ..., Johnson KC, Kuller LH, Robinson J, Women's Health Initiative and Women's Health Initiative Coronary Artery Calcium Study Investigators. Allison MA, Manson JE, Langer RD, Carr JJ, Rossouw JE, Pettinger MB, Phillips L, Cochrane BB, Eaton CB, Greenland P, Hendrix S, Hsia J, Hunt JR, Jackson RD, Johnson KC, Kuller LH, Robinson J, Women's Health Initiative and Women's Health Initiative Coronary Artery Calcium Study Investigators. Menopause. 2008 Jul Aug; 15(4 Pt 1):639-47
Mark Martens 18 Dec 2008
Background: Serum dehydroepiandrosterone (DHEA) concentrations decrease ∼80% between ages 25 and 75 yr. Aging also results in an increase in arterial stiffness, which is an independent predictor of cardiovascular disease (CVD) risk and mortality. Therefore, it is conceivable that DHEA replacement in older adults could reduce arterial stiffness. We sought to determine if DHEA replacement therapy in older adults reduces carotid augmentation index (AI) and carotid-femoral pulse wave velocity (PWV) as indices of arterial stiffness. Methods: A randomized, double-blind trial was conducted to study the effects of 50 mg/d DHEA replacement on AI (n=92) and PWV (n=51) in women and men aged 65-75 yr. Inflammatory cytokines and sex hormones were measured in fasting serum. Results: AI decreased in the DHEA group but not in the placebo group (difference between groups, -6±2 AI units, p=0.002). PWV also decreased (difference between groups, -3.5±1.0 m/sec, p=0.001); however, after adjusting for baseline values, the between-group comparison became non-significant (p=0.20). The reductions in AI and PWV were accompanied by decreases in inflammatory cytokines (TNFα and IL-6, p<0.05) and correlated with increases in serum DHEAS (r = -0.31 and -0.37, respectively, p<0.05). The reductions in AI also correlated with free testosterone index (r = -0.23, p=0.03). Conclusion: DHEA replacement in elderly men and women improves indices of arterial stiffness. Arterial stiffness increases with age and is an independent risk factor for CVD. Therefore the improvements observed in the present study suggest that DHEA replacement might partly reverse arterial aging and reduce CVD risk. © 2012 The Authors Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.
Copyright © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.
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