DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.
Cell. 2012 Jun 22; 149(7):1474-87
Zullo JM, Demarco IA, Piqué-Regi R, Gaffney DJ, ..., Bernstein BE, Pritchard JK, Reddy KL, Singh H. Zullo JM, Demarco IA, Piqué-Regi R, Gaffney DJ, Epstein CB, Spooner CJ, Luperchio TR, Bernstein BE, Pritchard JK, Reddy KL, Singh H. Cell. 2012 Jun 22; 149(7):1474-87
This outstanding article helps us understand an important part of the mechanism of transcriptional repression. In this study, the authors reveal DNA regions called LADs (lamina-associated domains) and LASs (lamina-associated sequences) that are responsible for the association of chromatin with the nuclear lamina, which in turn repress...
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