Sequence dependence of transcription factor-mediated DNA looping.
Nucleic Acids Res. 2012 Jun 19
Jim Maher
16 Jul 2012
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Confirmation, New Finding, Technical Advance
The lac operon was one of the first two genetic switches to be recognized and has been studied for 60 years. Despite deep analysis, the actual mechanism of the switch remains worthy of investigation through both theory and experiment. Indeed, our inability to understand this switch from first principles indicates just how audacious...
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