GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
Science. 2012 Apr 27; 336(6080):477-81
Marja Jaattela
11 Jul 2012
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New Finding, Novel Drug Target
Autophagy is a cellular process that allows cells to survive nutrient and growth factor deprivation by recycling their own contents. This paper describes how growth factor deprivation activates the core autophagy machinery by a novel protein phosphorylation-acetylation cascade.
Recent studies have elucidated the signaling pathways...
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