GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
Science. 2012 Apr 27; 336(6080):477-81
Lin SY, Li TY, Liu Q, Zhang C, ..., Wu J, Li Q, Han J, Lin SC. Lin SY, Li TY, Liu Q, Zhang C, Li X, Chen Y, Zhang SM, Lian G, Liu Q, Ruan K, Wang Z, Zhang CS, Chien KY, Wu J, Li Q, Han J, Lin SC. Science. 2012 Apr 27; 336(6080):477-81
Autophagy is a cellular process that allows cells to survive nutrient and growth factor deprivation by recycling their own contents. This paper describes how growth factor deprivation activates the core autophagy machinery by a novel protein phosphorylation-acetylation cascade.
Recent studies have elucidated the signaling pathways...
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