Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells.
Nucleic Acids Res. 2012 Mar 29
This article reports the surprising observation that the histone variant H2AX is not randomly distributed in the genome of cycling cells but is rather enriched at specific sites such as subtelomeric regions and highly expressed genes.
H2AX is phosphorylated by the ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and...
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