Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.
J Cell Biol. 2012 May 28; 197(5):677-89
Philip Ingham1 and Tom Carney2
17 Jul 2012
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New Finding
The Fraser complex consists of a heterotrimer of the large extracellular matrix proteins Fraser syndrome 1 (FRAS1), FRAS1-related extracellular matrix protein 2 (FREM2) and FREM1, which exist in a reciprocally stabilised complex. The complex has essential developmental roles in epidermal basement membrane attachment to the underlying...
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