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FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality.

Shalhoub V, Shatzen EM, Ward SC, Davis J ... Li X, Henley C, Eschenberg M, Richards WG Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, Bi V, Renshaw L, Hawkins N, Wang W, Chen C, Tsai MM, Cattley RC, Wronski TJ, Xia X, Li X, Henley C, Eschenberg M, Richards WG J Clin Invest. 2012 Jul 2; 122(7):2543-53

Helmy Siragy

23 Jul 2012 | Good for Teaching, Novel Drug Target

FGF23 (fibroblast growth factor 23) is a hormone that regulates phosphate excretion and vitamin D levels. It is produced by osteoblasts and osteocytes and mainly influences the kidney and parathyroid glands. Increased activity of FGF23 down regulates phosphate reabsorption in the kidney and inhibits vitamin D synthesis, leading...

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FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality.

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