Misannotations of rRNA can now generate 90% false positive protein matches in metatranscriptomic studies.
Nucleic Acids Res. 2011 Nov 1; 39(20):8792-802
David Ussery
02 Jul 2012
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Controversial, Good for Teaching, Interesting Hypothesis, New Finding
The rRNA operons are known to encode ribosomal RNAs, with occasional tRNAs. Most people know (or should know) that a 23S rRNA sequence does not encode a protein, although there can be a (rather poor) open reading frame in some cases. Examination of more than 9 million metagenomic reads has found that rRNA sequences are wrongly annotated...
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