Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome.
Sci Signal. 2012; 5(225):ra38
Howard Young
16 Jul 2012
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Good for Teaching, Interesting Hypothesis, New Finding
In this article, the authors delineate two pathways leading to the development of experimental autoimmune encephalomyelitis (EAE) in the mouse. One pathway, involving the Nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, is interferon sensitive through inhibition of the activation of Rac1 and the generation of reactive...
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