Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome.
Sci Signal. 2012; 5(225):ra38
In this article, the authors delineate two pathways leading to the development of experimental autoimmune encephalomyelitis (EAE) in the mouse. One pathway, involving the Nod-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, is interferon sensitive through inhibition of the activation of Rac1 and the generation of reactive...
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