Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Sci Transl Med. 2012 May 16; 4(134):134ra60
Goldstein LE, Fisher AM, Tagge CA, Zhang XL, ..., Cleveland RO, Tanzi RE, Stanton PK, McKee AC. Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC.
Sci Transl Med. 2012 May 16; 4(134):134ra60
All selected articles haveThis article has been added to your saved articles
You can follow/unfollow articles via MyF1000 or via the article or browse pages.
F1000Prime Recommendations, Dissents and Comments for [Goldstein LE et al., Sci Transl Med 2012, 4(134):134ra60]. In F1000Prime, 24 May 2013; F1000Prime.com/717348020
McKee AC, Stein TD, Nowinski CJ, Stern RA, ..., Budson AE, Goldstein LE, Kowall NW, Cantu RC. McKee AC, Stein TD, Nowinski CJ, Stern RA, Daneshvar DH, Alvarez VE, Lee HS, Hall G, Wojtowicz SM, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE, Kowall NW, Cantu RC. Brain. 2012 Dec 2
Phillip L Pearl and Clydette Powell 11 Jan 2013
Mac Donald CL, Johnson AM, Cooper D, Nelson EC, ..., Witherow JR, Fang R, Flaherty SF, Brody DL. Mac Donald CL, Johnson AM, Cooper D, Nelson EC, Werner NJ, Shimony JS, Snyder AZ, Raichle ME, Witherow JR, Fang R, Flaherty SF, Brody DL. N Engl J Med. 2011 Jun 2; 364(22):2091-100
Nyein MK, Jason AM, Yu L, Pita CM, Joannopoulos JD, Moore DF, Radovitzky RA. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20703-8
Robert Ruff 07 Jan 2011
Nampiaparampil DE. JAMA. 2008 Aug 13; 300(6):711-9
Donald Marion 03 Sep 2008
Long JB, Bentley TL, Wessner KA, Cerone C, Sweeney S, Bauman RA. J Neurotrauma. 2009 Jun; 26(6):827-40
James J Hill III 13 Nov 2009
Goodrich GL, Flyg HM, Kirby JE, Chang CY, Martinsen GL. Optom Vis Sci. 2013 Feb; 90(2):105-12
Roy G Cole 19 Mar 2013
Lew HL, Otis JD, Tun C, Kerns RD, Clark ME, Cifu DX. J Rehabil Res Dev. 2009; 46(6):697-702
Robert Ruff 13 Jan 2010
De Gasperi R, Gama Sosa MA, Kim SH, Steele JW, ..., Nambiar MP, Gandy S, Ahlers ST, Elder GA. De Gasperi R, Gama Sosa MA, Kim SH, Steele JW, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Dekosky ST, McCarron RM, Nambiar MP, Gandy S, Ahlers ST, Elder GA. Front Neurol. 2012; 3:177
Robert Ruff 29 Jan 2013
Pietrzak RH, Johnson DC, Goldstein MB, Malley JC, Southwick SM. J Nerv Ment Dis. 2009 Oct; 197(10):748-53
Robert Ruff 21 Jan 2010
Capó-Aponte JE, Urosevich TG, Temme LA, Tarbett AK, Sanghera NK. Mil Med. 2012 Jul; 177(7):804-13
Gregory Goodrich and Gary Martinsen 19 Sep 2012
Blast exposure is associated with traumatic brain injury (TBI), neuropsychiatric symptoms, and long-term cognitive disability. We examined a case series of postmortem brains from U.S. military veterans exposed to blast and/or concussive injury. We found evidence of chronic traumatic encephalopathy (CTE), a tau protein-linked neurodegenerative disease, that was similar to the CTE neuropathology observed in young amateur American football players and a professional wrestler with histories of concussive injuries. We developed a blast neurotrauma mouse model that recapitulated CTE-linked neuropathology in wild-type C57BL/6 mice 2 weeks after exposure to a single blast. Blast-exposed mice demonstrated phosphorylated tauopathy, myelinated axonopathy, microvasculopathy, chronic neuroinflammation, and neurodegeneration in the absence of macroscopic tissue damage or hemorrhage. Blast exposure induced persistent hippocampal-dependent learning and memory deficits that persisted for at least 1 month and correlated with impaired axonal conduction and defective activity-dependent long-term potentiation of synaptic transmission. Intracerebral pressure recordings demonstrated that shock waves traversed the mouse brain with minimal change and without thoracic contributions. Kinematic analysis revealed blast-induced head oscillation at accelerations sufficient to cause brain injury. Head immobilization during blast exposure prevented blast-induced learning and memory deficits. The contribution of blast wind to injurious head acceleration may be a primary injury mechanism leading to blast-related TBI and CTE. These results identify common pathogenic determinants leading to CTE in blast-exposed military veterans and head-injured athletes and additionally provide mechanistic evidence linking blast exposure to persistent impairments in neurophysiological function, learning, and memory.
has been added to your "Faculty I'm Following" page in MyF1000
Follow/Unfollow any Faculty via their recommendations, biography pages, or MyF1000