Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes.
J Immunol. 2011 Nov 15; 187(10):5268-76
Michel Desjardins1 and Kerstin Radtke2
28 Jun 2012
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Confirmation, New Finding
Autophagy has been recognised as an antiviral mechanism because of its ability to degrade intracellular pathogens and to contribute to antigen presentation. The present study links autophagy to another immune response: interferon (IFN)-beta- and tumor necrosis factor (TNF)-alpha-induced antiviral gene expression. The authors show...
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