HIV-1 Capture and Antigen Presentation by Dendritic Cells: Enhanced Viral Capture Does Not Correlate with Better T Cell Activation.
J Immunol. 2012 Jun 15; 188(12):6036-45
Rodriguez-Plata MT, Urrutia A, Cardinaud S, Buzón MJ, ..., Cedeño S, Clotet B, Moris A, Martinez-Picado J. Rodriguez-Plata MT, Urrutia A, Cardinaud S, Buzón MJ, Izquierdo-Useros N, Prado JG, Puertas MC, Erkizia I, Coulon PG, Cedeño S, Clotet B, Moris A, Martinez-Picado J. J Immunol. 2012 Jun 15; 188(12):6036-45
This paper dissected two important functions of dendritic cells (DCs) in HIV capture and presentation of HIV antigens to CD8+ T cells. Although both DC functions were enhanced when DCs matured, they were not necessarily correlated.
It is believed that DC plays a pivotal role in HIV infection by capturing viral particles and...
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