Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.
Nature. 2012 Jun 7; 486(7401):80-4
Dar AC, Das TK, Shokat KM, Cagan RL. Nature. 2012 Jun 7; 486(7401):80-4
This paper identifies new drugs to treat multiple endocrine neoplasia type 2B (MEN2B) disease using a Ret oncogene Drosophila model. This fascinating work shows how to perform a recent biomedical approach, combining pharmacology, protein biochemistry, cell biology, and animal model organisms. The authors show evidence that the inhibition...
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