Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat.
J Physiol. 2012 Sep 1; 590(Pt 17):4269-77
Abdala AP, McBryde FD, Marina N, Hendy EB, ..., Fudim M, Sobotka PA, Gourine AV, Paton JFR. Abdala AP, McBryde FD, Marina N, Hendy EB, Engelman ZJ, Fudim M, Sobotka PA, Gourine AV, Paton JFR. J Physiol. 2012 Sep 1; 590(Pt 17):4269-77
This paper provides important new evidence highlighting the role of the carotid body in the development and maintenance of hypertension.
Because the peripheral chemoreflex is enhanced in hypertensive individuals {1}, these investigators reasoned that denervating the carotid bodies would relieve the hypertension. They tested this...
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