Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.
Science. 2012 Jun 8; 336(6086):1314-7
Iliev ID, Funari VA, Taylor KD, Nguyen Q, ..., Wang HL, McGovern DP, Brown GD, Underhill DM. Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM. Science. 2012 Jun 8; 336(6086):1314-7
In this systematically thorough study, Iliev et al. emphasize two key points -- the mammalian gut microbiome is not the territory of bacteria alone, and the innate immune receptor dectin-1 is partially responsible for recognition of fungi in the gut. Specifically, the role of murine Clec7 is investigated in its capacity to curtail...
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