Re-splicing of mature mRNA in cancer cells promotes activation of distant weak alternative splice sites.
Nucleic Acids Res. 2012 Jun 6
Juan Valcárcel and Sophie Bonnal
20 Jun 2012
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New Finding
The authors report the occurrence of re-splicing events, i.e., splicing events occurring on an already processed mRNA. Such a mechanism is detected in two genes in cancer cells: human tumor susceptibility gene 101 (TSG101) and fragile histidine triad (FHIT). The authors argue that such a mechanism could contribute to diversity in...
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