Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain.
Neuron. 2012 May 24; 74(4):663-75
Bráz JM, Sharif-Naeini R, Vogt D, Kriegstein A, Alvarez-Buylla A, Rubenstein JL, Basbaum AI. Neuron. 2012 May 24; 74(4):663-75
This ground-breaking study convincingly demonstrates that transplantation of inhibitory neuronal precursors into the dorsal horn of the spinal cord can reverse mechanical allodynia after a peripheral nerve injury. The authors then prove that this reversal is due to functional integration of the transplanted cells into pain-transducing...
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