Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.
Nature. 2012 Jun 28; 486(7404):554-8
Neil Shear
20 Nov 2012
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New Finding
As noted, this takes the human leukocyte antigen (HLA) association from merely a statistical finding to the level of a mechanistic finding. This has broad implications for the understanding of drug-induced injury in all fields, not just dermatology, and impacts drug screening in development.
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