Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.
Nature. 2012 Jun 28; 486(7404):554-8
Illing PT, Vivian JP, Dudek NL, Kostenko L, ..., Burrows SR, Purcell AW, Rossjohn J, McCluskey J. Illing PT, Vivian JP, Dudek NL, Kostenko L, Chen Z, Bharadwaj M, Miles JJ, Kjer-Nielsen L, Gras S, Williamson NA, Burrows SR, Purcell AW, Rossjohn J, McCluskey J. Nature. 2012 Jun 28; 486(7404):554-8
As noted, this takes the human leukocyte antigen (HLA) association from merely a statistical finding to the level of a mechanistic finding. This has broad implications for the understanding of drug-induced injury in all fields, not just dermatology, and impacts drug screening in development.
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