Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Nature. 2011 Nov 20; 481(7381):380-4
Metallo C, Gameiro P, Bell E, Mattaini K, ..., Kelleher J, Vander Heiden M, Iliopoulos O, Stephanopoulos G. Metallo C, Gameiro P, Bell E, Mattaini K, Yang J, Hiller K, Jewell C, Johnson Z, Irvine D, Guarente L, Kelleher J, Vander Heiden M, Iliopoulos O, Stephanopoulos G. Nature. 2011 Nov 20; 481(7381):380-4
This article elucidates a role for glutamine and protein synthetic pathways in the interplay between carbohydrate and fatty acid utilization for energy production. In hypoxia, glycolysis is increased but tends to form lactate, not acetyl-CoA (AcCoA), and fatty acid metabolism is diminished. Glutamine use is increased above that...
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