The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.
Nature. 2012 Jun 14; 486(7402):266-70
Martin Fernandez-Zapico
24 Sep 2012
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New Finding
This study identifies the X-linked deubiquitinase USP9X as a new tumor suppressor gene for pancreatic cancer. Using the Sleeping Beauty transposon-mediated insertional mutagenesis system, the authors show that the loss of USPX9 accelerates KRAS-induced tumorigenesis and protects pancreatic cancer cells from anoikis. Further characterization...
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