Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.
Mol Cell. 2012 May 25; 46(4):424-35
Roberts SA, Sterling J, Thompson C, Harris S, ..., Malc E, Mieczkowski PA, Resnick MA, Gordenin DA. Roberts SA, Sterling J, Thompson C, Harris S, Mav D, Shah R, Klimczak LJ, Kryukov GV, Malc E, Mieczkowski PA, Resnick MA, Gordenin DA. Mol Cell. 2012 May 25; 46(4):424-35
The findings of this important study represent an exception to the traditional view that mutations occur haphazardly throughout the genome and accumulate over time. In both yeast and in some human tumors, the authors found that certain DNA clusters contained more mutations that occurred simultaneously than the rest of the genome....
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