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Relationship between deficits in overall quality of life and non-small-cell lung cancer survival.
J Clin Oncol. 2012 May 1; 30(13):1498-504
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31 May 2012
Confirmation
DOI: 10.3410/f.716197962.791552868
There is evidence that a clinically meaningful relationship exists between self-reported quality of life (QoL) of a patient with non-small-cell lung cancer (NSCLC) at the time of receiving the cancer diagnosis and overall survival. These findings have now been further confirmed by this large prospective...Continue reading
There is evidence that a clinically meaningful relationship exists between self-reported quality of life (QoL) of a patient with non-small-cell lung cancer (NSCLC) at the time of receiving the cancer diagnosis and overall survival. These findings have now been further confirmed by this large prospective study in 2442 lung cancer patients. Patient-reported QoL outcomes at the time of the cancer diagnosis can identify vulnerable patient subpopulations who are at risk of shortened survival. This paves the way for developing and testing interventions to apply when QoL deficits occur and to improve QoL and survival.
Disclosures
None declared
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van Zandwijk N: F1000Prime Recommendation of [Sloan JA et al., J Clin Oncol 2012, 30(13):1498-504]. In F1000Prime, 31 May 2012; DOI: 10.3410/f.716197962.791552868. F1000Prime.com/716197962#eval791552868
F1000Prime Recommendations, Dissents and Comments for [Sloan JA et al., J Clin Oncol 2012, 30(13):1498-504]. In F1000Prime, 19 May 2013; F1000Prime.com/716197962
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PURPOSE Evidence has suggested a clinically meaningful relationship between self-reported quality of life (QOL) of a patient with cancer at the time of receiving a cancer diagnosis and overall survival (OS). This study evaluated the prognostic value of QOL assessments with regard to OS in a large cohort of patients with lung cancer. PATIENTS AND METHODS A total of 2,442 patients with non-small-cell lung cancer were observed between 1997 and 2007 and completed a single-item measure of overall QOL within the first 6 months of receiving a lung cancer diagnosis; these were dichotomized using an a priori definition of a clinically deficient score (CDS; ≤ 50 v > 50). Kaplan-Meier estimates and Cox models were used to evaluate the prognostic importance of QOL on OS alone and in the presence of covariates. Logistic regression modeling was used to identify which clinical and patient characteristics were related to a clinically meaningful deficit in QOL. Results QOL deficits at time of lung cancer diagnosis were significantly associated with OS (hazard ratio [HR], 1.55; P < .001), as were performance status, older age, smoking history, male sex, treatment factors, and stage of disease. The median survival for patients with CDS QOL was 1.6 years versus 5.6 years for patients with non-CDS QOL. After controlling for all these covariates, the indication of a clinically deficient baseline QOL still contributed significantly to the prediction of patient survival (HR, 0.67; P < .001). CONCLUSION Overall QOL measured by a simple single item at the time of lung cancer diagnosis is a significant and independent prognostic factor for survival in patients with lung cancer.
PMID: 22454418
